CHEMISTRY 531

Survey of Organic Reactions

 

 

 

Syllabus and Course Schedule

 

Some Supplemental Notes from the Web:

 

Principles of Selectivity in Organic Reactions

 

 

Baldwin’s Rules for Ring Closure

 

Overheads week #1 (protecting groups)

 

Protecting Groups

 

Carbon-Carbon Bond Formation:

Enolate Alkyation

Organometallic Reagents

Sigmatropy

 

Overheads on Alkylation

 

Aldol Overheads

 

Felkin-Ahn Selectivity

 

Allylation Overheads

 

Olefination Reactions

 

Diels-Alder Reactions and the Formation of Six-Membered Rings

 

 

Diels-Alder Overheads

Olefins 1

 

Julia Reaction

 

Metathesis

 

Sigmatropy

 

Stille, Suzuki, Sonogashira Couplings

 

The Heck Reaction

 

Tsuji Trost Reaction

 

Sample Midterm

 

Oxidation 1

 

Oxidation 2

 

Oxidation Reactions

 

Asymmetric Reduction

 

Reduction Reactions

 

Organolithium, copper, zinc reagents

 

Organocatalysis

 

C-H activation/carbenes

 

Study Guide

 

 

Instructions for Final Presentations

 

 

Synthesis of Medium Rings

 

 Synthesis of Five-Membered Rings

 

Synthesis of Four-Membered Rings

 

Synthesis of Three-Membered Rings

 

Formation of Alkynes

 

 

 

Group 1:

 

 

 

Group 2:

 

 

 

Group 3:

 

 

 

 

Group 4:

 

 

 

 

 

Week 1:

 

Group 1

 

Group 2

 

Group 3

 

Group 4

 

 

Week 2:

 

Group 1

 

Group 2

 

 

Group 3

 

 

 

Group 4

 

 

 

Week 3:

 

 

Group 1

 

 

Group 2

 

 

Group 3

 

 

Group 4

 

 

 

 

 

 

Instructions for Final Presentation

 

 

Schedule for Final Presentations

 

Grading Rubric for Final Presentation

 

 

 

 

 

 

 

 

Notes courtesy of C.J. Rizzo, Vanderbilt University